Berlin 2012 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 12: Focus: Nonlinear Dynamics of the Heart (with DY)

BP 12.2: Hauptvortrag

Mittwoch, 28. März 2012, 10:00–10:30, MA 001

Modelling Excitation Contraction Coupling — •Martin Falcke — Max Delbrück Centrum für Molekulare Medizin Berlin

We present an efficient but detailed approach to modelling Ca²⁺-induced Ca²⁺ release in the diadic cleft of cardiac ventricular myocytes. We developed a spatial resolved Ca²⁺ release unit (CaRU), consisting of the junctional sarcoplasmic reticulum and the diadic cleft. Individaul channels are modelled by Markov chains. By taking advantage of time scale seperation, the model could be finally reduced to only one ordinary differential equation for describing Ca²⁺ fluxes and diffusion. Additionally the channel gating is described in a stochastic way. The resulting model is able to reproduce experimental findings like the gradedness of SR release, the voltage dependence of ECC gain and typical spark life time.