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BP: Fachverband Biologische Physik

BP 12: Focus: Nonlinear Dynamics of the Heart (with DY)

BP 12.3: Hauptvortrag

Mittwoch, 28. März 2012, 10:30–11:00, MA 001

Modeling of electrical and mechanical function of the heart — •Alexander Panfilov — Department of Physics and Astronomy, Gent University, Krijgslaan 281, S9, 9000 Gent, Belgium

Cardiac arrhythmias and sudden cardiac death is the leading cause of death accounting for about 1 death in 10 in industrialized countries. Although cardiac arrhythmias has been studied for well over a century, their underlying mechanisms remain largely unknown. One of the main problems in studies of cardiac arrhythmias is that they occur at the level of the whole organ only, while in most of the cases only single cell experiments can be performed. Due to these limitations alternative approaches such as mathematical modeling are of great interest. From mathematical point of view excitation of the heart is described by a system of non-linear parabolic PDEs of the reaction diffusion type with anisotropic diffusion operator. Cardiac arrhythmias correspond to the solutions of these equations in form of 2D or 3D vortices characterized by their filaments. In my talk I will briefly report on main directions of our research, such as development of virtual human heart model, and study organization of ventricular fibrillation due to dynamical instabilities in cardiac tissue and due to tissue heterogeneity. I will also report on modeling mechano-electric feedback in the heart using reaction-diffusion mechanics systems and ventricular fibrillation mechanisms due to deformation of cardiac tissue.