Bereiche | Tage | Auswahl | Suche | Aktualisierungen | Downloads | Hilfe
BP: Fachverband Biologische Physik
BP 17: Posters: Physics of Cells
BP 17.14: Poster
Mittwoch, 28. März 2012, 17:30–19:30, Poster A
Measuring local elasticity and membrane tension on differentiating cells — •Paula Sanchez1, Kai Bodensiek1, Schanila Nawaz2, Mikael Simons2, and Iwan Schaap1 — 1III Physikalisches Institut, Faculty of Physics, Georg-August Universität, Göttingen, Germany — 2Max-Planck Institute for Experimental Medicine, Göttingen, Germany
The myelin sheet is a specialized membrane structure that allows rapid conduction of nerve impulses and it is essential for the integrity of the axon. In the central nervous system it is produced by differentiation of oligodendrocytes in a multistep process accompanied by dramatic changes in cell morphology. Because cell shape is controlled by cellular mechanics we want to study the mechanical properties of oligodendrocytes in order to better understand the mechanics of cell differentiation. We are using a combination of atomic force microscopy and vertical laser trapping to quantify the spatial distribution of elasticity and membrane tension over the whole cell. With our results we aim to provide links between the mechanical development of these cells and changes in their physiology and morphology.