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BP: Fachverband Biologische Physik

BP 17: Posters: Physics of Cells

BP 17.16: Poster

Mittwoch, 28. März 2012, 17:30–19:30, Poster A

Device for mechanical stretching of adherent cells and application to pancreatic carcinoma cells (type:PANC-1) — •Patrick Paul, Tobias Paust, and Othmar Marti — Institute for Experimental Physics, Ulm University, Ulm, Germany

The structural and mechanical properties of cells are determined in part by the properties of their cytoskeleton systems. Healthy cells and cancerous cells were found to differ in their viscoelastic behavior. Softer cells were found to migrate faster through narrow channels.

The quasi-static viscoelastic behavior of cells is investigated with a deformable substrate. The stress and stress rate of the substrate is controlled. The response of the adherent cells is monitored by optical microscopy. Our apparatus contains an opto-mechanical feedback loop which centers the cell under investigation at the optical axis of the microscope. We report on the performance of our stretching device and we show first measurements with PANC-1 cells.