Berlin 2012 – wissenschaftliches Programm
Bereiche | Tage | Auswahl | Suche | Aktualisierungen | Downloads | Hilfe
BP: Fachverband Biologische Physik
BP 17: Posters: Physics of Cells
BP 17.21: Poster
Mittwoch, 28. März 2012, 17:30–19:30, Poster A
Three-dimensional templates produced by direct laser writing for dental implant surface optimization — •Judith Katharina Hohmann1, Erik Waller1, Rainer Wittig2, Rudolf Steiner2, and Georg von Freymann1 — 1Physics department and research center OPTIMAS, University of Kaiserslautern — 2Institute for Laser Technologies in Medicine and Measurement Technology (ILM) at the University of Ulm
Dental implant failure occurs in up to eight percent, usually resulting from deficit osseointegration or insufficient adaptation of soft tissue. Many approaches to improve dental implant acceptance deal with chemical and/or physical surface treatments (e.g. acid-etching, sand blasting) leading to randomly shaped two-dimensional patterns. These patterns lack true three-dimensional motifs with defined sizes. In general, results generated in two-dimensional systems can hardly be transferred to natural, three-dimensional systems.
Our aim is to understand the relation between various three-dimensional candidate structures and differentiation of osteoblastic cells and to use these results to generate implant surfaces which promote osseointegration.
Structures are produced by direct laser writing and coated with titanium dioxide. Smallest feature sizes realized yet are 330 nm, allowing to design and generate structures on both nano- and micrometer scale. To observe cellular behavior, osteosarcoma cells are applied to the structures in order to test growth, morphology, adhesion and differentiation via fluorescence and staining techniques.