Berlin 2012 – wissenschaftliches Programm

Bereiche | Tage | Auswahl | Suche | Aktualisierungen | Downloads | Hilfe

BP: Fachverband Biologische Physik

BP 18: Posters: Statistical Physics in Biological Systems

BP 18.17: Poster

Mittwoch, 28. März 2012, 17:30–19:30, Poster A

A facilitated diffusion model with two conformational states — •Maximilian Bauer¹ and Ralf Metzler^2,3 — ¹Physics Department, Technical University of Munich, Germany — ²Institute for Physics and Astronomy, Potsdam University, Germany — ³Physics Department, Tampere University of Technology, Finland

Transcription factors (TFs) such as the lac repressor find their target sequence on DNA at remarkably high rates. In the established facilitated diffusion model for this search process the TF alternates between three-dimensional diffusion in the bulk solution and one-dimensional sliding along the DNA chain. In similar models the TF was considered as being present in two conformations (search state and recognition state) between which it switches stochastically. Combining both approaches we obtain a generalised model, that comprises the previous models as special cases. We treat the bulk excursions explicitly for rod-like chains arranged in parallel and consider a simplified model for coiled DNA.