Berlin 2012 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 20: Regulation
BP 20.4: Vortrag
Donnerstag, 29. März 2012, 10:30–10:45, H 1058
Sources of Stochasticity in Protein Synthesis — •David Gomez1,2, Rahul Marathe1, and Stefan Klumpp1 — 1Max Planck Institute of Colloids and Interfaces, Science Park Golm, 14424 Potsdam, Germany. — 2Freie Universität Berlin, Arnimalle 14, 14195 Berlin, Germany
All living organisms are unique, even isogenic one in the same environmental conditions or have the same history. An explanation of such behavior is given by the fluctuations of the biochemical reactions within them. These fluctuations are become important when the number of the molecules involved in the biochemical reactions is low. Because the number of proteins, DNA, RNA are often small in the cell, one can expect large variation in the biochemical reactions.
The objective of this work is to model the variations of the protein synthesis in the by cell birth-death processes. To do that, we considered protein synthesis in cells, that after a cell division time, T , divide into two daughter cell. This process is done either in a deterministic or a stochastic way. In a first approximation the volume of the cells was not considered, but to describe protein concentrations, the growth and division of the cell volume was also incorporated into the model.
The consideration of the volume in our model, leaves us the opportunity to study regulatory cell processes, which are concentration-dependent, such as the negative feedback regulation model.