Berlin 2012 – scientific programme

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BP: Fachverband Biologische Physik

BP 20: Regulation

BP 20.5: Talk

Thursday, March 29, 2012, 10:45–11:00, H 1058

Consequences of degradation and aging of messenger RNA — •Carlus Deneke, Angelo Valleriani, and Reinhard Lipowsky — MPI für Kolloid- und Grenzflächenforschung, Department of Theory and Bio-Systems, Potsdam, Germany

In gene expression, the transcription and degradation of mRNA plays a central role. Various degradation mechanisms exist that actively regulate the stability of mRNA. The stability not only determines the steady state amount of mRNA in each cell, it sets also important time scales when transcription is either turned on or off.

In this contribution, we present a theoretical framework that describes various transient phenomena in gene expression. It extends previous studies as it is capable of considering various biochemical mechanisms of degradation. Furthermore, it also fully accounts for the stochasticity of both, transcription and degradation of mRNA. This framework will allow to describe the response of the cell to external stimuli which modulate the transcription of certain genes.