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BP: Fachverband Biologische Physik

BP 27: Posters: Cytoskeletal Filaments

BP 27.7: Poster

Donnerstag, 29. März 2012, 17:30–19:30, Poster A

How a polymer breaks a bond — •Sebastian Sturm, Jakob Bullerjahn, and Klaus Kroy — Institut für theoretische Physik, Universität Leipzig, Vor dem Hospitaltore 1, 04103 Leipzig

The unbinding kinetics of crosslinking proteins is a crucial ingredient to the rheological behavior of reversibly crosslinked polymer networks and cells. Whereas current models of cell rheology do account for the influence of crosslinker bindings on single-filament dynamics [1,2], the converse effect of polymer dynamics on unbinding kinetics has so far received less attention. Here we address this issue by investigating the unbinding kinetics of polymer-bound crosslinkers based on a rigorous description of subdiffusive monomer dynamics in terms of memory friction [3].

[1] L. Wolff, P. Fernandez, and K. Kroy, New Journal of Physics (2010)

[2] O. Lieleg, K. M. Schmoller, M. M. A. E. Claessens, and A. R. Bausch, Biophysical Journal 96, 4725-4732 (2009)

[3] J. Bullerjahn, S. Sturm, L. Wolff, and K. Kroy, epl (2011), doi 10.1209/0295-5075/96/48005