Berlin 2012 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 3: Statistical Physics of Biological Systems I (with DY)

BP 3.11: Vortrag

Montag, 26. März 2012, 12:15–12:30, MA 001

Modelling of DNA-Hybridization — •Olaf Leidinger and Ludger Santen — Universität des Saarlandes

Bringing together two types of single-stranded DNA molecules (targets: perfect matching and those with one mismatch) in a aqueous solution and one type of surface-attached single-stranded DNA molecules (probes) one can observe hybridization of double stranded DNA molecules. The percentage of perfect matching (PM) strands at the surface is found to be independent of the concentration of those with one mismatch (MM). This dominance is not in agreement with a Langmuir adsorption kinetics in contrast to the adsorption of a single species. We introduce a theoretical approach to the competitive adsorption of DNA strands illustrating the prerequisites for the dominant adsorption of PM DNA strands.