Berlin 2012 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 32: Physics of Cells III

BP 32.1: Vortrag

Freitag, 30. März 2012, 09:30–09:45, H 1028

Margination of white blood cells in microvessels — •Dmitry A. Fedosov, Julia Fornleitner, and Gerhard Gompper — Institute of Complex Systems, Forschungszentrum Juelich, Juelich, Germany

Margination of white blood cells (WBCs) towards microvessel walls is an essential pre-condition for their efficient adhesion to the vascular endothelium, which is a crucial step in the organism's immune response. WBC margination depends on hydrodynamic interactions of blood cells with the vessel walls as well as on their collective behavior and deformability. Numerical simulations with 2D and 3D blood flow models using the Dissipative Particle Dynamics method reveal a non-trivial dependence of WBC margination on blood hematocrit, flow rate, WBC deformability, and red blood cell (RBC) aggregation properties. In particular, WBC margination appears to be optimal within certain intermediate ranges of hematocrit and flow rate values, while beyond these ranges WBC margination is substantially attenuated. Moreover, RBC aggregation is found to enhance WBC margination in microvessels. We will present margination state diagrams, which identify WBC margination behavior for a wide range of flow and cell suspension conditions. These findings will help us better understand WBC margination and adhesion in microcirculation.