Berlin 2012 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 6: Physics of Cells II

BP 6.1: Hauptvortrag

Montag, 26. März 2012, 15:00–15:30, H 1028

Intercellular Interactions and the Mystery of Growth Control — •Lars Hufnagel — EMBL Heidelberg

Despite their obvious importance in animal development and disease, the mechanisms that control cell proliferation and tissue growth, are poorly understood. This talk will review the facts, issues and current ideas focusing on the problem of size determination in fly wing development. In particular while proliferation is driven cell autonomously by morphogen growth factors, it appears that the inhibitory control of growth depends on the global tissue-wide profile and history of growth. This global *integration* of growth is likely to be mediated by intercellular interactions involving both mechanics and cell-contact signaling.