Berlin 2012 – scientific programme
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BP: Fachverband Biologische Physik
BP 7: Posters: Proteins
BP 7.33: Poster
Monday, March 26, 2012, 17:30–19:30, Poster A
Single Peptide Desorption from Solid Surfaces — •Susanne Liese1, Nadine Schwierz2, and Roland Netz1 — 1FU Berlin, Germany — 2TU Munich, Germany
The desorption of single homopeptides from solid surfaces is examined by molecular dynamic (MD) simulations and analytical calculations. To investigate the role of the surface hydrophobicity on peptide desorption, the relation between the hydrophobicity of a self-assembled monolayer (SAM) with non-polar terminal groups and the force necessary to desorb different homopeptides from such surfaces is investigated by MD simulations. For the purely non-polar surfaces the desorption force decreases with increasing surface hydrophobicity and increases with increasing peptide hydrophobicity. Additionally, the equilibrium and non-equilibrium effects of the finite polymer length on the forced desorption of single polymers by AFMs, is examined in the framework of a freely jointed chain and a worm-like chain-model. With these rather simple models experimental observations from the group of Prof. Thorsten Hugel at TU Munich are successfully described, such as the dependency between rupture length and desorption force. Furthermore, the question, to which extent the desorption process is reversible, is addressed.