Berlin 2012 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 8: Posters: Biopolymers and Biomaterials (with CPP)
BP 8.16: Poster
Montag, 26. März 2012, 17:30–19:30, Poster A
Lipid-Coated Implant Materials under Load — •Martin Kreuzer1,2, Matthias Reinhardt2, Markus Strobl3, Jochen Stahn4, Maksym Golub5, Regine Willumeit5, Reiner Dahint1, and Roland Steitz2 — 1Universität Heidelberg, Deutschland — 2Helmholtz-Zentrum Berlin, Deutschland — 3European Spallation Source, Schweden — 4Paul-Scherrer Institut, Schweiz — 5Hemholtz-Zentrum Geesthacht, Deutschland
In the last decade, the search for biocompatible materials has become a major topic in medical research. In that context coating of implants by lipid layers seems an obvious strategy for achieving better acceptance of the implant in the human organism. The combination of suitable metallic implants with lipid coverage is most promising for forthcoming implant modifications. Here, one of the fundamental requirements is the reliable preparation of stable lipid coatings on the implant surfaces. We investigated the stability of oligolamellar lipid bilayers prepared by spin coating on silicon discs and titanium-coated silicon substrates against an excess water phase under shear load by neutron reflectivity. We evaluated a critical temperature region at which a stack of DMPC lipid bilayers detaches from titanium-coated and bare silicon surfaces, respectively, against heavy water under shear load. The critical temperature region coincides with the main phase transition temperature of DMPC in excess heavy water. The experimental setup made it possible to follow the unbinding process on a molecular scale. Our experiments did not show a significant difference between the lipid coatings on bare silicon and titanium coated silicon supports.