Berlin 2012 – scientific programme

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CPP: Fachverband Chemische Physik und Polymerphysik

CPP 16: Poster: Colloids and Complex Liquids

CPP 16.31: Poster

Tuesday, March 27, 2012, 18:15–20:45, Poster A

Microfabrication of a 3D asymmetric flow profile for chiral separations — •Carina Vosskötter, Lukas Bogunovic, and Dario Anselmetti — Experimental Biophysics and Applied Nanoscience, Faculty of Physics, Bielefeld University, Bielefeld, Germany

Chiral molecules (enantiomers) are molecules with the same molecular formula that can be transformed into the respective other isomer only by mirroring. Even if enantiomers - except for their optical activity - yield identical physical properties, they can still have completely different biochemical effects with respect to the metabolism of living organisms. At the present time, industrially synthesized chiral drugs are separated as far as required so that 25 % of all them are administered as pure enantiomers.

We conceived an alternative selector-free and continuously working concept to separate chiral objects within a lab-on-a-chip device. We show that it is possible to separate (asymmetric) chiral micro-objects within an asymmetric micro flow profile with a yield of 85 %.

Furthermore this so far two-dimensional concept is expanded into full 3D by introducing a novel two-component assembly strategy for the microchip, that can allow for a complex surface modification protocol to break the symmetry in every relevant dimension.