Berlin 2012 – wissenschaftliches Programm
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CPP: Fachverband Chemische Physik und Polymerphysik
CPP 27: Poster: (Hydrogels) and Elastomers
CPP 27.5: Poster
Mittwoch, 28. März 2012, 11:00–13:00, Poster A
Star-PEG-Heparin-Polyelectrolyte-Hydrogels - Network Structure — •Ron Dockhorn1,2 and Jens-Uwe Sommer1,2 — 1Leibniz Institute of Polymer Research Dresden, D-01069 Dresden, Germany — 2Technische Universität Dresden, Institute for Theoretical Physics, D-01069 Dresden, Germany
We are studying a new class of biohybrid hydrogels made of heparin, a rod-like highly charged glycosaminoglycan as a highly functionalized cross-linker, and non-charged, elastic 4-star-shaped-polyethylene glycol. We focus on the network structure by using the bond-fluctuation simulation method and determine the defects, the topological arrangement, and percolation threshold of the gels. Also, we investigate the influence of the initial molar ratio, the variations of functionalized groups, and the concentration dependence of the reaction mixture. We developed a mean-field type model to understand the combined effects of counterions and a good solvent on the swelling properties of the gels [1]. It has been shown that this interplay leads to nearly constant heparin concentration in the swollen gel under physiological conditions, while large variations of the degree of swelling and the storage modulus are accessible. This gels allow a constant release of heparin-binding signaling molecules while independently controlling the mechanical properties to optimize matrices with both mechanical and biomolecular features for cell replacement-based therapies.
[1] Sommer, J.-U., Dockhorn, R. et al., Swelling Equilibrium of a Binary Polymer Gel, Macromolecules 2011 44 (4), 981-986