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CPP: Fachverband Chemische Physik und Polymerphysik

CPP 9: Biopolymers and Biomaterials (joint session with BP)

CPP 9.2: Vortrag

Dienstag, 27. März 2012, 10:00–10:15, H 1058

Molecularly imprinted conductive polymers for controlled trafficking of neurotransmitter at solid-liquid interfaces — •Neelima Paul^1,2, Markus Mueller¹, Amitesh Paul³, Elke Guenther⁴, Iver Lauermann¹, Peter Müller-Buschbaum², and Martha Ch. Lux-Steiner¹ — ¹Helmholtz-Zentrum Berlin für Materialien und Energie GmbH, Hahn-Meitner-Platz 1, 14109 Berlin, Germany — ²TU München, Physik-Department, LS Funktionelle Materialien, James-Franck-Str. 1, 85747 Garching, Germany — ³TU München, Physik-Department, LS Neutronenstreuung, James-Franck-Str. 1, 85748 Garching, Germany — ⁴Natural and Medical Sciences Institute at the University of Tübingen, Markwiesenstr. 55, 72770 Reutlingen, Germany

The state of the art approach to restore sight in certain cases of blindness is the replacement of the damaged photoreceptors by a subretinal implant consisting of light-sensitive photodiodes . We suggest to chemically stimulate the neurons by replacing the photodiodes in the subretinal implant by a molecularly imprinted polymer (MIP), imprinted with a neurotransmitter, such as glutamate. By controlling the neurotransmitter trafficking across a solid-liquid interface with voltage, we show the possibility of using this MIP for chemical stimulation of retinal neurons. ATR-FTIR spectroscopy and XPS has been used to chemically confirm the imprint of neurotransmitter in the MIP at the solid-liquid and the solid-air interface respectively. Fluorescence spectroscopy using the dye, fluorescamine, has been used to monitor the changes in neurotransmitter concentration in various solvents.