Stuttgart 2012 – scientific programme

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MO: Fachverband Molekülphysik

MO 12: Femtosecond Spectroscopy III

MO 12.5: Talk

Tuesday, March 13, 2012, 15:15–15:30, V38.03

Femtosecond mid-infrared study on the photochemistry of a CO-releasing compound in water — •Philipp Rudolf¹, Florian Kanal¹, Dominik Gehrig¹, Johanna Niesel², Tobias Brixner¹, Ulrich Schatzschneider², and Patrick Nuernberger¹ — ¹Institut für Physikalische und Theoretische Chemie, Universität Würzburg, Am Hubland, 97074 Würzburg, Germany — ²Institut für Anorganische Chemie, Universität Würzburg, Am Hubland, 97074 Würzburg, Germany

In recent years, biological applications of CO-releasing molecules (CORMs), which may be utilized as an in-situ source for carbon monoxide, an endogenous gasotransmitter in the human body, have been demonstrated. Especially promising are water-soluble metal carbonyl complexes which can act as dark-stable prodrugs under physiological conditions. One of these compounds is the [Mn(CO)₃(tpm)]Cl (tris(pyrazolyl)methane (tpm) manganese tricarbonyl) complex which undergoes photoinduced CO release upon UV irradiation.

So far, the carbon monoxide liberation has mostly been studied on a macroscopic scale and at rather long irradiation times of several minutes. In this study we want to reveal the ultrafast primary processes of CO release and the incipient reactions involved. For this purpose, we employ time-resolved mid-infrared spectroscopy with different pump wavelengths, exposing an ultrafast dissociation process accompanied by the formation of new species. These experiments are complemented by linear spectroscopy methods and DFT calculations on the reactant as well as on a range of possible photoproducts.