Stuttgart 2012 – wissenschaftliches Programm
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P: Fachverband Plasmaphysik
P 17: Laserplasmen und innovative Anwendungen
P 17.7: Vortrag
Donnerstag, 15. März 2012, 12:00–12:15, V55.01
Plasma sterilization of pharmaceutical products: from basics to production — •Benjamin Denis1, Simon Steves1, Egmont Semmler1,2, Nikita Bibinov1, Wenzel Novak2, and Peter Awakowicz1 — 1Lehrstuhl fur Allgemeine Elektrotechnik und Plasmatechnik, Ruhr-Universitat Bochum, Deutschland — 2groninger & co gmbh, Crailsheim, Deutschland
Sterilization is a crucial step in pharmaceutical packaging and filling. Conventional sterilization methods used in pharmaceutical industry e.g. highly toxic chemicals (e.g. ethylene oxide), autoclaves or gamma radiation are not suitable for all kinds of pharmaceutical products, due to material damaging.
The route from a laboratory plasma reactor to an industry scale plasma sterilization reactor is shown. Absolutely calibrated measurements yield to a knowledge transfer from an experimental set-up to a prototype and a industrial plasma reactor. It was shown that UV and VUV radiation is needed to kill (endo)spores. Langmuir probe measurements reveal that a discharge with a homogeneous distribution of the electron density around large objects is possible. Temperature measurements show that the gas temperature and therefore the energy impact on materials cannot be neglected. With both high power and lowering the duty-cycle it is possible to achieve relatively high UV/VUV dosages, but also keeping the thermal load low.
High sterilization efficiency of 4 log spore count reduction in 10 s of Geob. stearothermophilus and B. subtilis spores prove the applicability of an industrial grade plasma sterilization reactor.