Stuttgart 2012 – wissenschaftliches Programm

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SYIB: Symposium Fast Ion Beams in Nuclear, Atomic and Molecular Physics Research

SYIB 2: Fast Ion Beams in Nuclear, Atomic and Molecular Physics Research II

SYIB 2.1: Hauptvortrag

Dienstag, 13. März 2012, 14:00–14:30, V55.22

Ion induced fragmentation of large (bio)molecules — •Thomas Schlathölter — KVI Atomic and Molecular Physics, University of Groningen , Zernikelaan 25, 9747AA Groningen, The Netherlands

The advantage of fast ions for cancer therapy lies in their unique dose-distribution in human tissue. At a well-defined depth ions are slowed down to MeV energies and cell killing is most effective due to maximum linear energy transfer and radiobiological effectiveness. Such volume sensitivity renders ion-therapy a superior tool for a number of localized tumors, in some cases decreasing the yearly risk of radiation induced development of lethal secondary tumors by up to one order of magnitude! To date, many molecular mechanisms underlying biological radiation action remain unclear and particularly the exceptional cell killing efficiency of heavy ions and protons is largely unexplored on the molecular level. In this talk I will show that ion collisions with gas phase DNA, proteins and their building blocks are an excellent approach to study molecular mechanisms underlying ion-therapy. Controlled attachment of water molecules even allows to study solvation effects on ion induced fragmentation in the gas-phase.