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Q: Fachverband Quantenoptik und Photonik

Q 43: Poster II

Q 43.22: Poster

Mittwoch, 20. März 2013, 16:00–18:30, Empore Lichthof

Cancer cell therapy by upcoversion UV emission from Pr:YAG nanoparticles — Kangwei Xia¹, •Gengxu Chen^1,2, Andrea Zappe¹, Rolf Reuter¹, Rainer Stöhr¹, Tugrul Inal¹, Jan Meijer³, Roman Kolesov¹, and Jörg Wrachtrup¹ — ¹3. Physikalisches Institut, Universität Stuttgart, Pfaffenwaldring 57, Stuttgart, D-70569, Germany — ²State Key Laboratory of Precision Spectroscopy, East China Normal University, Shanghai, 200062, China — ³RUBION, Ruhr-Universität Bochum, Bochum, D-44780, Germany

Recently, rare-earth ions doped inorganic crystals have been introduced into cellular microscopic studies as new types of biomarkers due to optical upconversion process [1]. Furthermore, optical upconversion process in rare-earth doped materials can produce ultraviolet (UV) emission with visible or even infrared excitation. If such nanoparticles are located inside living cells, the cells will be killed by the UV emission with an appropriate excitation on the nanoparticles [2]. Here, we demonstrated the apoptosis of the HeLa cells incubated in a buffer containing Pr:YAG nanoparticles, which is on account of the photochemical effect caused by upconversion UV emission of Pr:YAG nanoparticles [2,3]. Our study might pave a way to novel methods of laser-assisted cancer treatment.

Reference [1] F. Wang and X. Liu, Chem. Soc. Rev. 38, 976-989 (2009) [2] R. Kolesov, K. Xia, R. Reuter, R. Stöhr, A. Zappe, J.Meijer, P.R. Hemmer, and J.Wrachtrup, Nat. Commun. 3:1029 doi: 10.1038/ncomms2034 (2012). [3] R. Kolesov, R. Reuter, K. Xia, R. Stöhr, A. Zappe, and J. Wrachtrup, Phys. Rev. B 84, 153413 (2011)