Regensburg 2013 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 25: Posters: Cytoskeleton

BP 25.6: Poster

Mittwoch, 13. März 2013, 17:30–19:30, Poster C

Feedback mechanism for microtubule polymerization regulation — •Maria Zeitz and Jan Kierfeld — Physics Department, TU Dortmund, Dortmund, Germany

We investigate the feedback mechanism in the cell between a polymerizing microtubule and the proteins Rac and stathmin and its role in microtubule length regulation. We use two different approaches to investigate the impact of the feedback mechanism: On the one hand, we construct a homogeneous model, which neglects spatial concentration variations and focuses on the feedback effects in the reaction kinetics. This model can be solved analytically. On the other hand, we introduce a more detailed model which couples reactions to diffusion of stathmin proteins and polymerization dynamics of the microtubule. We investigate the the complex dynamics of all three components by stochastic simulations.