Regensburg 2013 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 26: Posters: Biomaterials and Biopolymers (joint with CPP)
BP 26.10: Poster
Mittwoch, 13. März 2013, 17:30–19:30, Poster C
Mechanical strength and intracellular uptake of CaCO3-templated layer-by-layer capsules composed of biodegradable polyelectrolytes — Raghavendra Palankar1, Bat-El Pinchasik2, Stephan Schmidt2, Bruno De Geest3, Andreas Fery4, Helmuth Möhwald2, André Skirtach5,6, and •Mihaela Delcea1,2 — 1ZIK HIKE, Ernst-Moritz-Arndt-Universität Greifswald, Greifswald 17489, Germany — 2Max-Planck Institute of Colloids and Interfaces, Golm 14424, Germany — 3Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent 9000 Belgium — 4Physikalische Chemie II, Universität Bayreuth, Universitätsstrasse 30, D-95447 Bayreuth, Germany — 5Department of Molecular Biotechnology, Ghent University, Ghent 9000, Belgium — 6NB-Photonics, Ghent University, Ghent 9000, Belgium
Developing carriers comprised of biomaterials and capable of withstanding significant mechanical pressures, structural deformations and at the same time delivering biomolecules is of high interest for drug delivery. Using colloidal probe AFM combined with fluorescence microscopy, the mechanical and release properties from CaCO3-templated polymeric capsules made of biodegradable polymers are studied in comparison with those of CaCO3-templated capsules composed of synthetic polymers. The influence of the number of polyelectrolyte layers on the mechanical properties and release from biodegradable capsules will be shown. Mechanical deformation of capsules upon their intracellular uptake is determined and the implications for microcapsule design are discussed.