Regensburg 2013 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 26: Posters: Biomaterials and Biopolymers (joint with CPP)
BP 26.2: Poster
Mittwoch, 13. März 2013, 17:30–19:30, Poster C
Artificial hydroxyapatite pellets - mimicking hard tissues with simple surfaces — •Christian Zeitz1, Samuel Grandthyll1, Deniz Kahraman2, Peter Loskill1, Jörg Schmauch1, Nicolas Thewes1, Frank Müller1, and Karin Jacobs1 — 1Experimental Physics, Saarland University, Saarbrücken, Germany — 2Institute for ceramics in engineering, KIT, Karlsruhe, Germany
The interactions of proteins, cells or bacteria with hard tissue surfaces are of utmost importance. On the one hand, characterization of these interactions often employs simplified model surfaces featuring low roughness and controlled surface chemistry (mica, glass, silicon wafers). Thereby specific properties of tissue compounds such as hydroxyapatite are not included. Previous studies showed, however, that hydroxyapatite interacts with attaching proteins in a specific way. On the other hand, the drawback of tissue samples instead of model systems is the lack of controllability or reproducibility. Both approaches are necessary for a comprehensive understanding of the principles on the natural material but limited both in their own way.
Therefore, we have developed substrates consisting of hydroxyapatite featuring a low roughness and defined chemical composition. The local roughness is comparable to the one of silicon wafers. The chemical purity as well as the simple structure allow for controlled characterization of fundamental interactions. Using these samples, we investigate the adhesion of bacteria and adsorption of proteins on natural substrates.