Regensburg 2013 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 26: Posters: Biomaterials and Biopolymers (joint with CPP)

BP 26.7: Poster

Mittwoch, 13. März 2013, 17:30–19:30, Poster C

Development of hydrogel-based antiviral wound dressings — •Julian Riba and Oliver Lieleg — Zentralinstitut für Medizintechnik, Technische Universität München, Garching, Germany

Mucus is a biopolymer-based hydrogel that lines most of the inner surface in humans and animals and serves as a first layer of protection against pathogenic microorganisms. Recently, it has been shown in vitro that purified porcine gastric mucin biopolymers can act as a broad-spectrum antiviral agent. Yet, the low viscosity of reconstituted mucin solutions hampers their direct application for wound treatment. In this work, we aim to develop a novel mucin-based material for wound dressings. This novel material is supposed to maintain the antiviral properties of mucins while allowing for in situ gelation for easy application on inner wounds. We investigate composites of porcine gastric mucin and other gel-forming polymers such as methylcellulose, alginate, and chitosan so that gelation of the mixed polymer system can be induced by temperature or chemical crosslinking. Sample characterization is performed using macrorheological measurements and optical microscopy.