Regensburg 2013 – scientific programme

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BP: Fachverband Biologische Physik

BP 27: Biotechnology and Bioengineering

BP 27.1: Topical Talk

Thursday, March 14, 2013, 09:30–10:00, H43

DNA Origami: Applications in Physics and Biotechnology — •Tim Liedl — Center for Nanoscience, LMU, Munich, Germany

DNA Nanotechnology makes use of programmable DNA strands for the construction of self-assembling two- and three-dimensional objects of nano-engineered shapes [1]. Through the introduction of the extremely robust DNA origami technique [2] the field experienced exciting developments during the last years. I will present recent applications of DNA origami in physics and biotechnology and will show, e.g., how the method can be employed for the fabrication of self-assembled plasmonic materials [3, 4]. Through literally nanometer-precise control over the arrangement of nanoparticles, we were able to create chiral plasmonic structures that exhibit pronounced circular dichroism and optical rotatory dispersion. In recent experiments we were able to orient the nanoparticle helices and observe increased optical activity. These results demonstrate the potential of DNA origami for the assembly of plasmonic metafluids with tailored optical properties.

1. N. C. Seeman, "Nanomaterials based on DNA", Annu. Rev. Biochem. 79, 12.1-12.23 (2010). 2. P. W. K. Rothemund, "Folding DNA to create nanoscale shapes and patterns", Nature 440, 297*302 (2006). 3. A. Kuzyk et al., "DNA-based Self-Assembly of Chiral Plasmonic Nanostructures with Tailored Optical Response", Nature 483, 311-314 (2012). 4. D. Smith et al., "Nucleic Acid nanostructures for nanomedicine applications", Nanomedicine 8, in press (2013)