Regensburg 2013 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 33: Statistical Physics in Biological Systems IV (joint with DY)
BP 33.6: Vortrag
Freitag, 15. März 2013, 10:45–11:00, H44
In vivo facilitated diffusion model — •Maximilian Bauer1,2 and Ralf Metzler1,3 — 1Institute for Physics and Astronomy, Potsdam University, Germany — 2Physics Department, Technical University of Munich, Germany — 3Physics Department, Tampere University of Technology, Finland
In vitro transcription factors (TFs) alternate between three-dimensional bulk diffusion and sliding along DNA in order to quickly find their target on DNA. Recent experiments showed that also in the crowded interior of living cells TFs employ this facilitated diffusion mechanism. For a theoretical description of the situation in vivo we use a simple model of the bacterial genome embedded in an experimentally identified subvolume of the cell. Explicitly taking into account the configuration of DNA, our findings agree with experimental results and suggest that cells operate near to conditions which are optimal for target localization.
References: M. Bauer and R. Metzler, Biophys. J. 102, 2321 (2012) and submitted (2012)