Regensburg 2013 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 5: Cytoskeleton
BP 5.6: Vortrag
Montag, 11. März 2013, 16:30–16:45, H43
Cell membrane deformation and its role during cytokinesis — •Jochen A. M. Schneider1, Andrea M. Pereira2, Ewa Paluch2, and Guillaume Salbreux1 — 1Max Planck Institute for the Physics of Complex Systems, Dresden, Germany — 2Max Planck Institute of Cell Biology and Genetics, Dresden, Germany
Cytokinesis, the process of physically dividing the cell at the end of mitosis, is achieved through the regulated variations of forces within the cell. A key player in this process is the cell cortex, a thin layer of actin filaments and myosin molecular motors. Recently, Sedzinski et al. have introduced a mathematical model to describe the role of the cell cortex in cytokinesis. The model has shown that because of the contractile behavior of the cell cortex, the cell shape can be unstable with respect to symmetry breaking, and that cell elasticity is required for cell shape stability. We present here a potential role of the cell membrane in contributing to cell elasticity. The membrane is attached to the cell cortex and has to mechanically balance the difference between extracellular and intracellular pressure. Under simple hypothesis on the membrane mechanical behavior and its area regulation by the cell, we investigate how its interaction with the cortex influences cell shape.