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CPP: Fachverband Chemische Physik und Polymerphysik

CPP 4: SYBD: Magnetic Nanoparticles in Biomedical Diagnostics and Therapy

CPP 4.2: Hauptvortrag

Montag, 11. März 2013, 15:30–16:00, H1

Fluid mechanical aspects of therapeutic application of suspensions of magnetic nanoparticles — •Stefan Odenbach — TU Dresden, Chair of Magnetofluiddynamics, Measuring and Automation Technology, Dresden, Germany

One of the promising approaches for the use of magnetic nanoparticles in cancer therapy is a technique called magnetic drug targeting. Here a chemotherapeutic agent is attached to the surfactant of the magnetic particles and a water based suspension of these drug carrying particles is injected into a supplying artery of the tumour. Using appropriate magnetic fields magnetic forces can be generated targeting the particles towards the tumour. As a result chemotherapy without side effects is envisaged.

Within the talk some of these aspects resulting from fluid mechanics will be highlighted and discussed. On the one hand we'll have a look on model experiments studying the targeting process for the magnetic fluid and its dependence on magnetic field configuration. The respective experiments presented will be accompanied by numerical simulations which are intended to provide a tool for future clinical applications allowing an optimal field control on the basis of angiographic data.

The second part of the talk will focus on magnetic field effects concerning the viscosity of ferrofluids for biomedical applications as well as on changes of the flow behaviour of blood with suspended magnetic particles in a field and will thus highlight investigations on fundamental fluid properties being important for experiments as well as simulations.