Regensburg 2013 – wissenschaftliches Programm
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CPP: Fachverband Chemische Physik und Polymerphysik
CPP 44: Wetting, Micro- and Nanofluidics
CPP 44.3: Vortrag
Donnerstag, 14. März 2013, 15:45–16:00, H39
Microfluidic Rocking ratchet for the separation of magnetically labeled cells — •Lars Helmich1, Matthias Schuermann2, Alexander Auge1, Frank Wittbracht1, Christian Kaltschmidt2, and Andreas Huetten1 — 1Thin films and Physics of Nanostructures, Department of Physics, Bielefeld University — 2Department of Cell Biology, Bielefeld University
The aim of so called lab-on-a-chip devices is to integrate all laboratory tasks on one microfluidic chip. Employing magnetic materials particularly magnetic beads in these systems has gained great interest during the last decades [1,2].
One way of controlling and directing the motion of magnetically functionalized particles is the use of Rocking ratchet structures [3].
We present a separation device consisting of a micro structured spatially periodic array of conduction lines beneath a microfluidic channel and an additional external magnetic gradient field. Human embryonic kidney cells were labeled with magnetic beads. Depending on the choice of field strengths and switching times it is possible to separate cells by diffusivity and magnetic moment. Parameter optimization studies were carried out by means of finite element method based numerical simulations.
[1] A. Auge et al., Appl. Phys. Lett 94, 183507 (2009)
[2] N. Pamme, Lab On A Chip, 6(1) 24-38 (2006)
[3] P. Reimann, Physics Reports, 361 57-265 (2002)