Regensburg 2013 – wissenschaftliches Programm
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DF: Fachverband Dielektrische Festkörper
DF 12: Poster 1
DF 12.27: Poster
Dienstag, 12. März 2013, 10:30–13:30, Poster D
3D soft x-ray imaging of magnetite coated microballoons for theranostic applications — •Andreas Späth1, Hanno Dietrich1, Birgit Graf-Zeiler1, Gaio Paradossi2, and Rainer H. Fink1 — 1Friedrich-Alexander Universität Erlangen-Nürnberg, Physical Chemistry II and ICMM, Erlangen, Germany — 2Università di Roma Tor Vergata, Dipartimento di Scienze e Tecnologie Chimiche, Rome, Italy
Poly(vinylalcohol) stabilized microballoons (diameter 4 - 10 microns) are promising hybrid systems for various applications in theranostics. Their surface can easily be functionalized chemically, and they can be filled with a large variety of therapeutic gases, thus providing very good contrast agents in ultrasound imaging. By embedding superparamagnetic iron oxide nanoparticles (SPIONs) into the polymer shell magnetic field guidance and even a magnetothermally triggered drug release from these micro containers is possible. This could be a highly valuable progress in selective destruction of tumor cells with highly active pharmazeuticals.
Within this contribution we will clarify the shell morphology and SPION distribution in various batches of magnetically functionalized PVA microballoons by transmission soft x-ray microspectroscopy (TXM) and TEM and extend these investigations to third dimension by reconstructions of TXM focal series and x-ray holography. X-ray magnetic dicroism (XMCD) and SQUID measurements were applied for a basic magnetic characterization of the particles.