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DY: Fachverband Dynamik und Statistische Physik

DY 36: Statistical Physics in Biological Systems IV (joint with BP)

DY 36.3: Vortrag

Freitag, 15. März 2013, 10:00–10:15, H44

Efficacy of ribosome-targeting antibiotics determined by a non-linear molecular race — •Philip Greulich^1,2, Martin R. Evans², and Rosalind J. Allen² — ¹Cavendish Laboratory, University of Cambridge — ²School of Physics and Astronomy, University of Edinburgh

Many antibiotics in current clinical use target bacterial ribosomes. We present a dynamical model for the response of a cell to a ribosome-targeting antibiotic. In this model, the efficacy of the antibiotic is determined by a non-linear "molecular race" between binding of the antibiotic to ribosomes and net production of new ribosomes. The model points to a non-trivial growth-rate dependence of the minimum inhibitory concentration (MIC) and predicts a discontinuous transition at the MIC when the antibiotic concentration is varied: the growth rate abruptly drops to zero at this point. Furthermore, the efficacy of an antibiotic treatment depends on both its intensity and duration, and we can determine the relation to critical pharmacokinetic/-dynamic parameters for cell killing.