Regensburg 2013 – wissenschaftliches Programm
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HL: Fachverband Halbleiterphysik
HL 59: Goup IV elements and their compounds I
HL 59.3: Vortrag
Mittwoch, 13. März 2013, 15:30–15:45, H15
Organophosphonate-Based PNA-Functionalization of Silicon Carbide — •Matthias Sachsenhauser1, Dominik Weinbrenner1, Matthias Moritz1, Kung-Chiang Liao2, Jeffrey Schwartz2, Martin Stutzmann1, Jose Garrido1, and Anna Cattani-Scholz1 — 1Walter Schottky Institut, Technische Universität München, 85748 Garching, Germany — 2Princeton University, USA
Inorganic semiconductors combined with bio-organic systems offer the potential for the development of a wide range of novel biohybrid devices. In this context, silicon carbide (SiC) is a particularly promising substrate material because it features a high chemical stability and biocompatibility, making it ideal for biomedical and biosensing applications. However, a fundamental requirement for using SiC in biosensing applications is the ability to immobilize tailored molecular and biomolecular layers on this semiconductor's surface. Recently, we have demonstrated covalent functionalization of n-type 6H-SiC with organophosphonates. Structural and chemical properties of these monolayers were investigated through atomic force mircroscopy (AFM), X-ray photoelectron spectroscopy (XPS), contact potential difference (CPD) and Fourier-transform infrared spectroscopy (FTIR) measurements, revealing covalent bonding of the phosphonates to both (0001)- and (000-1)-oriented 6H-SiC crystal faces. Here we describe the potential of hydroxyl-terminated SAMs for the tailored biofunctionalization of (0001) 6H-SiC surfaces. In particular, we have focused our work on the covalent immobilization of peptide nucleic acid (PNA) oligonucleotides, which are receptors for DNA hybridization.