Regensburg 2013 – wissenschaftliches Programm
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ST: Fachverband Strahlen- und Medizinphysik
ST 2: Advances in X-Ray Imaging I
ST 2.1: Vortrag
Mittwoch, 13. März 2013, 15:00–15:20, H41
Pulmonary Emphysema Diagnosis using a preclinical small-animal x-ray Dark-Field Scanner — •Andre Yaroshenko1, Felix Meinel2, Martin Bech1, Arne Tapfer1, Astrid Velroyen1, Konstantin Nikolaou2, Alexander Bohla3, Ali Önder Yildirim3, Oliver Eickelberg3, Maximilian Reiser2, and Franz Pfeiffer1 — 1Department of Physics Technische Universität München, Germany — 2Institute of Clinical Radiology, Ludwig-Maximilians-University Hospital Munich, Germany — 3Institute of Lung Biology and Disease, Helmholtz Zentrum Munich, Germany
Pulmonary emphysema is one of the leading causes of morbidity and mortality worldwide that is difficult to detect using conventional x-ray radiographic methods. For emphysematous lungs with enlarged distal airspaces, x-ray scattering decreases and transmission increases, as has been demonstrated by the proof-of-principle experiments with brilliant x-rays from a synchrotron source. Therefore, combination of the transmission and dark-field signals leads to a novel diagnostic approach for pulmonary emphysema.
In this study, images of excised murine lungs with pulmonary emphysema and control lungs were acquired using a compact phase- and dark-field scanner with a polychromatic source and a cone-beam geometry. The data analysis revealed a clear distinction between the two groups in the per-pixel scatter plot. The main difference was observed in the angle of the distribution to the vertical.
The presented study reveals the high potential of the approach for the pulmonary emphysema diagnosis.