Regensburg 2013 – wissenschaftliches Programm

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SYBD: Symposium Magnetic Nanoparticles in Biomedical Diagnostics and Therapy

SYBD 1: Magnetic Nanoparticles in Biomedical Diagnostics and Therapy

SYBD 1.4: Hauptvortrag

Montag, 11. März 2013, 16:30–17:00, H1

Superparamagnetic iron oxide nanoparticles for MR-visible mesh implants and novel drug targeting models — •Ioana Slabu^1,2, Anjali Roeth³, Christiane Kuhl⁴, Thomas Schmitz-Rode¹, and Martin Baumann¹ — ¹Applied Medical Engineering, Medical Faculty, Helmholtz Institute, RWTH Aachen University, Germany — ²II. Physical Institute, RWTH Aachen University, Germany — ³Department of Surgery, University Hospital, RWTH Aachen University, Germany — ⁴Department of Radiology, University Hospital, RWTH Aachen University, Germany

Two major medical applications of superparamagnetic iron oxide (SPIO) nanoparticles are presented, exploiting their physical and magnetic properties to combine diagnostic and therapeutic functionalities. First, the concept and realization of a (magnetic resonance) MR-visible mesh implant is described which facilitates an accurate determination of complications after mesh implantation by means of MR imaging. The visual investigation of the implant helps to reduce the exposure of the patient to redundant surgery interventions. Second, magnetic drug targeting approaches based on numerical simulations for cancer therapies are developed. A new concept of placing an array of permanent magnets and coils inside hollow organs of the body very close to tumors is described. In this way, a stronger magnetic field and its higher gradient are achieved in the tumor. This allows a local accumulation of administrated SPIO nanoparticles with bounded drugs and enhances the efficiency of the therapy. First simulation results are already applied and validated in animal trials.