Berlin 2014 – scientific programme
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P: Fachverband Plasmaphysik
P 26: Laser Plasmas II
P 26.3: Talk
Thursday, March 20, 2014, 17:00–17:15, SPA HS202
Realizing a laser-driven electron source applicable for radiobiological tumor irradiation — •Maria Nicolai1, Alexander Sävert1, Maria Reuter1,2, Michael Schnell1, Jens Polz1, Oliver Jäckel1,2, Leonhard Karsch3, Michael Schürer3, Melanie Oppelt3, Jörg Pawelke3,4, and Malte C. Kaluza1,2 — 1Institute of Optics and Quantum Electronics, Jena — 2Helmholtz-Institute Jena — 3OncoRay, National Center for Radiation Research in Oncology, Dresden — 4Institute of Radiation Physics, Dresden
Laser-accelerated electron pulses have been used to irradiate human tumors grown on mice’s ears during radiobiological experiments [1]. These experiments have been carried out with the JETI laser system at the Institute of Optics and Quantum Electronics in Jena. To treat a total of more than 50 mice, a stable and reliable operation of the laser-electron accelerator with a dose rate exceeding 1 Gy/min was necessary. To achieve this, a sufficient number of electrons at energies in excess of 5 MeV had to be generated. The irradiation time for a single mouse was a few minutes. Furthermore, these particle-pulses’ parameters needed to remain achievable for a time period of several weeks. Due to the on-line detection of the radiation dose, the unavoidable shot-to-shot fluctuations, currently still typical for laser-based particle accelerators, could be compensated. The results demonstrate that particle pulses generated with laser-based accelerators have the potential to be a future alternative for conventional particle accelerators used for the irradiation of tumors. [1] M. Nicolai et al., Appl. Phys. B, DOI 10.1007/s00340-013-5747-0 (2013)