Dresden 2014 – scientific programme

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BP: Fachverband Biologische Physik

BP 10: Posters: Molecular Motors

BP 10.8: Poster

Tuesday, April 1, 2014, 09:30–12:30, P1

Dynamics of diffusing particles interacting with directionally moving particles on a polar filament — •Denis Johann, Debajit Goswami, and Karsten Kruse — Saarland University, Saarbrücken, Germany

During cell division, pairing of sister chromosomes and their segregation is driven by the mitotic spindle, which is a stable bipolar structure consisting of overlapping microtubules, motor and other associated proteins. However, how the interplay between these proteins and microtubules render stability to the spindle structure is still unknown. Passive mobile cross-linkers called Ase1 have been found to dynamically adapt the dynamics of microtubule sliding induced by molecular motors to the length of the microtubules' overlap region [1].

Here, we study the effect of Ase1 on molecular motors in presence of steric interactions in terms of a stochastic lattice model. We find that the Ase1 accumulate towards the end of the lattice in the direction of motor hopping and characterise their distribution through a mean-field theory.

[1] Braun et al., Nature Cell Biology 13, 1259-1264 (2011)