Dresden 2014 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 2: DNA/RNA and related enzymes

BP 2.10: Vortrag

Montag, 31. März 2014, 12:15–12:30, ZEU 250

RNA folding dynamics studied with structure based models — •Michael Faber and Stefan Klumpp — Max Planck Institute of Colloids and Interfaces Potsdam-Golm Science Park; Am Mühlenberg 1 OT Golm; 14476 Potsdam; Germany

RNA molecules form well defined three-dimensional structures on physiologically relevant timescales which are crucial for their enzymatic activity. Already during transcription structured RNA can have regulatory functions. Key to RNA folding is the formation of intramolecular base pairs which is called the secondary structure. We have developed a structure-based model of RNA and use a kinetic Monte-Carlo method to study the dynamics of secondary structures. We apply our methods to the folding and unfolding of several RNA structures in the presence and absence of external load forces. To study the effect of transcription on folding we look at co-transcriptional folding of riboswitches.