Dresden 2014 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 20: Cell adhesion, mechanics and migration I

BP 20.7: Vortrag

Dienstag, 1. April 2014, 15:15–15:30, HÜL 386

Blood platelet dynamics on structuredsubstrates — •Rabea Sandmann and Sarah Köster — University of Göttingen, Institut for X-Ray Physics, Friedrich-Hund Platz 1, 37077 Göttingen, Germany

Blood platelets are the first cells to interact with implants and build a scaffold into which other cells are embedded. The implant’s surface texture plays an important role for platelet behavior and thus for the correct incorporation of implants into the body. We investigate the reaction of platelets to microstructured surfaces by studying their spreading dynamics as well as the formation of cell protrusions (filopodia and lamellipodia). We observe, that on structured substrates, spreading takes more time than on flat substrates. This may be attributed to the decreased number of filopodia and the preference of these filopodia for certain directions. The spread area over time shows a sigmoidal shape and its turning point coincides with the transition from filopodia to lamellipodia. The phase of cellular retraction that follows spreading starts primarily over the holes. This behavior can be explained, since the parts of the cell that span over the holes are probably the mechanically most instable parts. When the spread area has decreased to values close to those at the turning point, new filopodia are formed. This leads us to the conclusion that platelets can detect their area and react to an area decrease by formation of filopodia to start the spreading process anew.