Dresden 2014 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 35: The Collapsed State of Polymers: From Physical Concepts to Applications and Biological Systems (Symposium SYCP, joint CPP/BP/DY)

BP 35.4: Hauptvortrag

Donnerstag, 3. April 2014, 11:15–11:45, HSZ 02

Modeling dynamic spatial genome organization in yeast — •Christophe Zimmer — Institut Pasteur, 25 rue du Docteur Roux, 75015 Paris

The spatial organization and dynamics of chromosomes plays important roles for gene expression, DNA repair and replication, but its underlying principles remain poorly known. We will present quantitative experimental data and simulation results showing that the territorial organization the interphase yeast nucleus and the dynamics of chromosomes can be largely predicted by a model based on generic polymer physics with a minimal set of DNA sequence-specific constraints and assumptions. We will also discuss extensions of our budding yeast model to other organisms and address implications of this model for a quantitative understanding of DNA repair.