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Dresden 2014 – scientific programme

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BP: Fachverband Biologische Physik

BP 39: The Collapsed State of Polymers: From Physical Concepts to Applications and Biological Systems (accompanying session, joint CPP/BP/DY)

BP 39.8: Talk

Thursday, April 3, 2014, 17:15–17:30, ZEU 250

Membrane-driven collapse of DNA macromolecules and semiflexible filamentous virus particlesAnastasiia B. Artemieva1, Christoph Herold2, Andrey G. Cherstvy3, Petra Schwille1, and •Eugene P. Petrov11Max Planck Institute of Biochemistry, 82152 Martinsried, Germany — 2BIOTEC, Technische Universität Dresden, 01307 Dresden, Germany — 3University of Potsdam, 14476 Potsdam-Golm, Germany

Interaction of (bio)macromolecules and colloidal particles with lipid membranes is one of the important problems of the modern bio-inspired soft matter physics. Earlier, we have found [1] that interaction of DNA molecules with strongly charged freestanding cationic lipid bilayers [2] leads membrane-mediated coil-globule transition of membrane-absorbed DNA macromolecules. Our recent experimental observations show that membrane-driven interactions at higher membrane charge densities are strong enough to induce the membrane-mediated collapse of much stiffer fd virus particles (lp ∼ 2.2 µm). We discuss these experimental findings in the framework of our new theoretical treatment [3] which takes into account membrane-polyelectrolyte electrostatic interactions, local membrane deformations, and polyelectrolyte bending rigidity.

[1] C. Herold, P. Schwille, and E. P. Petrov, Phys. Rev. Lett. 104 (2010) 148102.

[2] C. Herold, G. Chwastek, P. Schwille, and E. P. Petrov, Langmuir 28 (2012) 5518.

[3] A. G. Cherstvy and E. P. Petrov, PCCP (2014) in press.

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