Dresden 2014 – scientific programme

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BP: Fachverband Biologische Physik

BP 41: Biomaterials and Biopolymers II (joint CPP/BP)

BP 41.7: Invited Talk

Thursday, April 3, 2014, 16:45–17:15, ZEU 222

Threading DNA through nanopores for biosensing applications — •Maria Fyta — Insitute for Computational Physics, University of Stuttgart

The use of nanopores to read-out in an ultra-fast and cheap way the information inherent in DNA is being intensively investigated the last two decades. A biomolecule, like DNA, in a salt solution is electrophoretically threaded through a nanometer sized pore altering the ionic current that flows through the pore. Simultaneously, measuring the transverse tunneling currents across the nanopore can possibly lead to distinguishable electronic signatures for each DNA unit. Here, we will review some of our work related with the statistical and dynamical characteristics of the translocation process and the ionic current through the pore as obtained through multiscale simulations. Using more accurate simulations we will then report on our attempts to optimize the nanopore. Our efforts are focused on proper functionalization of the nanopore in order to enhance the transverse ionic current for reading-out the genetic information in DNA.