Dresden 2014 – scientific programme

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BP: Fachverband Biologische Physik

BP 42: Biotechnology and bioengineering

BP 42.7: Talk

Friday, April 4, 2014, 11:15–11:30, HÜL 386

Biocompatibility of Fe₇₀Pd₃₀ ferromagnetic shape memory films for cell sensing — •Mareike Zink¹, Uta Allenstein¹, Yanhong Ma², Florian Szillat², and Stefan G. Mayr^2,3 — ¹Division of Soft Matter Physics, Institute for Experimental Physics I, Universität Leipzig, Germany — ²Leibniz-Institut für Oberflächenmodifizierung (IOM) e.V., Leipzig — ³Translationszentrum für Regenerative Medizin and Fakultät für Physik und Geowissenschaften, Universität Leipzig, Germany

Ferromagnetic shape memory alloys (FSMAs) have received great attention recently as an exciting class of smart functional materials. In comparison to conventional shape memory alloys, FSMA bear the significant potential for miniaturized devices for single cell actuation which is capable of yielding magnetically controllable shear strains and/or volume dilations of several percent. However, biocompatibility of this material remains to be confirmed. Our in vitro assessments show that various cell types adhere and proliferate well on Fe-Pd. Since adhesion and spreading is mediated by the interaction of the amino acid sequence RGD which binds to integrin receptors on the cell surface, we further compared the interaction of RGD molecules with Fe-Pd by ab initio simulation, delamination and cell tests. We could demonstrate that the adhesion force of RGD with Fe-Pd is larger compared to the binding strength of RGD with integrin receptors - a prerequisite for good bioactivity of the surface.