Dresden 2014 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 43: Neurosciences
BP 43.3: Vortrag
Freitag, 4. April 2014, 10:15–10:30, ZEU 250
Asymmetric two-trace model for STDP — •Rodrigo Echeveste and Claudius Gros — Institut für Theoretische Physik, Johann Wolfgang Goethe Universität, Max-von-Laue-Str. 1, Frankfurt am Main, Germany
In the present work we propose a simple model formulating synaptic potentiation and depression in terms of two interacting traces, representing the fraction of open NMDA receptors and the Ca2+ concentration in the post-synaptic neuron, respectively. These two traces then determine the evolution of the synaptic weight. We first test that the standard STDP curve for low frequency trains of pairs of pre- and post-synaptic spikes is obtained and we then evaluate high frequency effects. Secondly, we study triplets. In this case, we are interested in non-linear effects and, in particular, in possible asymmetric response to pre-post inversion.
Having a low number of parameters and composed of only polynomial differential equations, the model is able nonetheless to reproduce key features of LTP and LTD. Moreover, since the parameters of the model are easily related to the dynamical properties of the synapse, it permits to make a connection between the observed synaptic weight change and the behaviour of the underlying traces.