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BP: Fachverband Biologische Physik
BP 43: Neurosciences
BP 43.4: Talk
Friday, April 4, 2014, 10:30–10:45, ZEU 250
Including intrinsic thalamic currents in a population model of the thalamo-cortical system during deep sleep — Michael Schellenberger Costa1, Arne Weigenand1, Thomas Martinetz1, and •Jens Christian Claussen2,1 — 1INB, Universität zu Lübeck, Germany — 2Computational Systems Biology Lab, Research II, Jacobs University Bremen, Germany
Sleep has been shown to be beneficial for the consolidation of memories [1, 2]. As the thalamocortical
interaction is important for both the processing of sensory stimuli and the generation
of slow waves a detailed understanding of its dynamical properties is needed, to
reveal the influence of one on the other. Population models have been used to investigate
the behaviour of awake brain networks [3,4,5]. These models lack the hallmarks of a sleeping
thalamus e.g. rebound bursts and waxing/waning of spindles
[6]. Therefore we adapt a cortical population model proposed [7] and extend it with the respective
intrinsic properties specific in the RE and TC neurons.
[1] L. Marshall et al, Nature, 444, 610 (2006)
[2] H V V Ngo et al, J Sleep Res (2013), Neuron (2013).
[3] M. Ursino et al, NeuroImage, 52,
(2010).
[4] R. C. Sotero et al, Neur
Comp 19, 478 (2007)
[5] B S Bhattacharya et al, Neural Networks 24, 631
(2011).
[6] A Destexhe, T J Sejnowski, Physiol Rev 83, 1401 2003)
[7] D. Steyn-Ross et al,
J Biol
Phys 31, 547 (2005)