Dresden 2014 – scientific programme

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BP: Fachverband Biologische Physik

BP 43: Neurosciences

BP 43.7: Talk

Friday, April 4, 2014, 11:15–11:30, ZEU 250

Computer simulation of the distribution of histone deacetylases 1 and 3 in the brain — •Davoud Pouladsaz — Department of Biological Physics, Max Planck Institute for the Physics of Complex Systems, Dresden, Germany

Since their abnormal activities have been implicated in various neurological disorders, including oncogenesis, neurodegenerative and psychiatric disorders, histone decaetylases (HDACs), a class of enzymes that alter the chromosome structure and affect the gene expression, are potential targets for therapeutic development. Therefore, understanding the distribution of HDACs in the brain can serve as a valuable tool in this regard. We perfom Monte Carlo simulations in order to calculate the distribution of HDAC1 and HDAC3 in the brain based on previous experimental results of patterns of histone acetylation in the brain in response to MS-275, a benzamide derivative with in vivo antitumor activity and selectivity against HDAC1 and HDAC3. The results show significant correlation to experimental measurements.