Dresden 2014 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 6: Posters: Membranes and vesicles
BP 6.12: Poster
Montag, 31. März 2014, 17:30–19:30, P3
Interaction of amphiphilic triblock copolymers with lipid bilayer membranes: Monte-Carlo simulations — •Hauke Rabbel1,2, Marco Werner1,2, and Jens-Uwe Sommer1,2 — 1Leibniz-Institut für Polymerforschung Dresden, Germany — 2Technische Universität Dresden - Institute for Theoretical Physics
Amphiphilic ABA triblock copolymers show interesting behaviour in their interactions with lipid membranes.
For example PEO-PPO-PEO, also known under the trademark Pluronics, have found applications in pharmaceutical
contexts both as membrane sealents and permeabilizers. Despite their applications, the nature of the
interaction with cellular membranes is not yet fully understood.
Here we study the interactions of different types of ABA triblock copolymers with lipid bilayer membranes
using the bond fluctuation model with explicit solvent[1,2]. We consider polymers with different
A- and B-block lengths under variation of the relative hydrophobicities of the constituents.
The results indicate that the surface active behaviour of ABA triblock copolymers adsorbed at lipid membranes
can be understood by their hydrophilic-lipophilic balance, as supported by recent experimental observations[3].
Triblock copolymers with purely hydrophilic A-blocks and a well chosen hydrophobicity of the B-blocks may
find use as membrane-active agents, when fixed in a membrane spanning conformation.
I.Carmesin and K.Kremer, Macromolecules 1988, 21, 2819-2823
M. Werner, J.-U. Sommer, V.A. Baulin, Soft Matter 2012, 8, 11714
Wang, Marks, Lee, Biomacromolecules 2012, 13, 2616-2623