Dresden 2014 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 6: Posters: Membranes and vesicles

BP 6.5: Poster

Montag, 31. März 2014, 17:30–19:30, P3

Coarse-grained simulations of membranes interacting with amyloid fibril forming peptides — •André Kesser and Friederike Schmid — Johannes Gutenberg-Universität Mainz, Mainz

We are developing a generic coarse-grained model to investigate nucleation of amyloid peptides in the presence of lipid membranes. To this end, we combine a simple lipid membrane model developed in our group with a peptide model proposed by S. Auer and coworkers, which is derived from the popular tube model. Both peptides and lipids are represented by linear stiff chains connected by beads, with additional angular potentials, non-bonded Lennard-Jones type interactions and (in the case of peptides) additional hydrogen bonds. Currently we are building a c++ based Software to investigate these models by Monte Carlo and Molecular Dynamics simulations. We describe the model and present first results.