Dresden 2014 – scientific programme

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BP: Fachverband Biologische Physik

BP 7: Posters: Cell adhesion, mechanics and migration

BP 7.11: Poster

Monday, March 31, 2014, 17:30–19:30, P3

Diffusion heterogeneities in cells during Mitosis — •Nisha Pawar and Matthias Weiss — Experimental Physics-I University of Bayreuth, Bayreuth, Germany

The Cytoplasm of the eukaryotic cell is highly complex and dynamic in nature. In addition, it is highly structured on many length scales. There are random motions within crowded and heterogeneous cytoplasm via protein complexes and organelles. Therefore diffusion behavior in cytoplasm can be expected to show spatial variations and a dependence on the cell cycle. The formation of mitotic spindle during the metaphase is expected to add another layer of complexity to the diffusion behavior of protein in the cytoplasm. We have probed the diffusion behavior of protein in cytoplasm during interphase and metaphase by Fluorescence Correlation Spectroscopy (FCS). Our results indicate that protein mobility not only heterogeneous in each of these states but also apparent mobility pattern depends on the cell cycle.