Dresden 2014 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 7: Posters: Cell adhesion, mechanics and migration
BP 7.13: Poster
Montag, 31. März 2014, 17:30–19:30, P3
Influence of direct laser written three-dimensional topographies on osteoblast-like cells — •Judith K. Hohmann1 and Georg von Freymann1,2 — 1Physics Department and Research Center OPTIMAS, University of Kaiserslautern — 2Fraunhofer Institute for Physical Measurement Techniques IPM, Department of Materials Characterization and Testing, Kaiserslautern
Biological cells react to various signals of their environment. While biochemical pathways have been investigated for decades, the influence of physical characteristics of the cellular environment has only been studied in the very recent past. Especially information on the interaction with three-dimensional structures is barely available, since common chemical and/or physical surface treatments (e.g. acid-etching, sand blasting) lead to randomly shaped surface topographies.
Our well-defined three-dimensional templates are fabricated by direct laser writing and coated with titanium dioxide via atomic layer deposition. This allows us to provide biocompatible substrates with nearly arbitrary micro structures.
We report on how geometric parameters influence viability parameters of osteoblast-like cells. We observe a significantly higher proliferation on particular topographies compared to unstructured surfaces. Additionally, an influence of structural parameters on the morphology and focal adhesion contacts of osteoblast-like cells is obtained and differentiation is verified via alkaline phosphatase staining. Our results might lead to novel dental implant surfaces which promote osseointegration.